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KMID : 0363320090300040780
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Journal of Korean Oriental Internal Medicine
2009 Volume.30 No. 4 p.780 ~ p.787
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Acute Toxicity Study on Fermented Ssanghwa-tang Extracts in Mice
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Lee Ji-Hye
Um Young-Ran
Shim Ki-Shuk
Jeon Won-kyung
Lee Jae-Hoon
Ma Jin-Yeul
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Abstract
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Purpose: This study was carried out to investigate the acute toxicity and safety of fermented Ssanghwa-tang extract.
Methods: To evaluate their acute toxicity and safety, 0(control group), 1250, 2500 and 5000 mg/kg of Ssanghwa-tang and fermented Ssanghwa-tang extracts were orally administered to 20 male and 20 female ICR mice. After a single administration, we observed survival rates. general toxicity. changes of body weight, and autopsy.
Results: Compared with the control group, we could not find any toxic alteration in any of the treated groups (1250, 2500 and 5000 mg/kg).
Conslusions:LD50 of Ssanghwa-tang and fermented Ssanghwa-tang extracts might be over 5000 mg/kg and it is very safe for ICR mice.
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KEYWORD
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Ssanghwa-tang, Fermentation, Acute toxicity, Safety, LD50
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